Causes And Types Of Vasculitis /Autoimmune



Vasculitis is the result of inflammation of the blood vessels that occurs when the body attacks any of the body’s blood vessels this includes arteries, arterioles, veins, and capillaries.

AutoimmuneInflammation caused by this condition will cause the blood vessels to thicken and narrow, reducing blood flow.

This will result in a decreased amount of essential nutrients and oxygen supplied to the body’s tissues.

Alternatively, the blood vessels may react differently to inflammation and cause weakening of the blood vessel walls and develop an aneurysm, a potentially fatal condition.




This disease can range in severity from mild, requiring little therapy, to severe multi-system illness that involves specialized medical care.

Autoimmune and Inflammatory diseases

The etiology of this condition is not clear, but can be associated with infection, allergic or hypersensitivity reactions, certain cancers and immune system disorders, and infections.

  • Vasculitides are subdivided into two different categories, primary and secondary. 

  • Additionally, they are further classified by type and size of vessels involved and he location of the inflamed vessel. 

  • The ability to classify allows greater understanding of its origination and optimizes treatment for each case.



Primary vasculitides occur with no known cause and occurs on its own. When primary vasculitis involves a number of organ systems it is referred to as primary systemic.  

Vasculites TypesThese types of vasculitides include, but are not limited to the following conditions.




Giant cell arteritis, also called temporal arteritis, is the involvement of the large arteries of head and neck, primarily the temporal artery. In some cases, the blood supply to the eye is affected, which could lead to blindness.

Takayasu Arteritis is the inflammation of the aorta, the main artery from the heart, and its large branches. This is a slow progressing narrowing of the blood vessels and reduces the blood supply to the extremities and other parts of the body.

Kawasaki disease is a rare condition that inflicts young children and causes inflammation of the small and medium-sized arteries.

Wegener’s granulomatosis is a rare condition that encompasses the blood vessels of the skin, lungs, eye, and kidney.

Behcet’s Syndrome is characterized by unpredictable inflammation of small blood vessels throughout the body. It causes recurrent outbreaks of ulcers in the mouth, genitals, inside the eyes, and other body parts. There is no known cause for this disease, however, viral or environmental factors may cause the immune system to respond differently.

Buerger’s Disease is associated with the use of tobacco products and causes decreased circulation to the hands and feet.

AutoimmuneChurg Strauss syndrome, also called allergic granulomatosis or angiitis, causes inflammation of the nose, asthma, and an increase of eosinophils. Most commonly the lungs, sinuses, skin, and peripheral nerves are involved, although, the heart, stomach, kidneys, and central nervous system are not excluded.

Henoch-Schönlein purpura results in red spots on the skin caused by the inflammation of blood vessels in the skin. Inflammation within the kidneys is also common.

Microscopic Polyangiitis causes swelling of the small and medium blood vessel walls and can involve the kidneys, lungs, sinuses, joints, and skin.

Secondary vasculitides are characterized by inflammation triggered by an allergic reaction to a drug or toxin, an infection, or in association with cancer or an autoimmune disorder.

Polyarteritis nodosa is caused by hepatitis B viral infection. Cryoglobulinemia occurs in response to the hepatitis C virus.

Rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, and dermatomyositis can cause inflammation of the blood vessels.



Blood Test Autoimmune

Blood test can show whether you have abnormal levels of certain blood cells and antibodies in your blood.

People diagnosed with lupus are also at higher risk of developing fibromyalgia, but studies are ongoing to relate the occurrence of fibromyalgia with secondary vasculitis.

Blood cell cancers such as lymphoma and leukemia can affect the blood vessels by causing inflammation.