Causes And Types
Of Vasculitis /Autoimmune
Vasculitis is the result of inflammation of the
blood vessels that occurs when the body attacks any of the body’s blood vessels this includes arteries,
arterioles, veins, and capillaries.
Inflammation caused by this condition will cause
the blood vessels to thicken and narrow, reducing blood flow.
will result in a decreased amount of essential nutrients and oxygen supplied to the body’s
Alternatively, the blood vessels may react differently to
inflammation and cause weakening of the blood vessel walls and develop an aneurysm, a potentially fatal
This disease can
range in severity from mild, requiring little therapy, to severe multi-system illness that involves specialized
Autoimmune and Inflammatory diseases
etiology of this condition is not clear, but can be associated with infection, allergic or hypersensitivity
reactions, certain cancers and immune system disorders, and infections.
Vasculitides are subdivided into two
different categories, primary and secondary.
Additionally, they are further classified
by type and size of vessels involved and he location of the inflamed vessel.
The ability to classify
allows greater understanding of its origination and optimizes treatment for each
Primary vasculitides occur with no known cause and
occurs on its own. When primary vasculitis involves a number of organ systems it is referred to as primary
These types of vasculitides include, but are not limited to the following
arteritis, also called temporal arteritis, is the involvement of the large arteries of head and neck, primarily the
temporal artery. In some cases, the blood supply to the eye is affected, which could lead to
Takayasu Arteritis is the inflammation of the aorta, the main artery from the
heart, and its large branches. This is a slow progressing narrowing of the blood vessels and reduces the blood
supply to the extremities and other parts of the body.
Kawasaki disease is a rare
condition that inflicts young children and causes inflammation of the small and medium-sized arteries.
Wegener’s granulomatosis is a
rare condition that encompasses the blood vessels of the skin, lungs, eye, and kidney.
Behcet’s Syndrome is
characterized by unpredictable inflammation of small blood vessels throughout the body. It causes recurrent
outbreaks of ulcers in the mouth, genitals, inside the eyes, and other body parts. There is no known cause for this
disease, however, viral or environmental factors may cause the immune system to respond differently.
Buerger’s Disease is associated
with the use of tobacco products and causes decreased circulation to the hands and feet.
syndrome, also called allergic granulomatosis or angiitis, causes inflammation of the nose,
asthma, and an increase of eosinophils. Most commonly the lungs, sinuses, skin, and peripheral nerves are
involved, although, the heart, stomach, kidneys, and central nervous system are not excluded.
results in red spots on the skin caused by the inflammation of blood vessels in the skin. Inflammation within the
kidneys is also common.
Microscopic Polyangiitis causes
swelling of the small and medium blood vessel walls and can involve the kidneys, lungs, sinuses, joints, and
Secondary vasculitides are
characterized by inflammation triggered by an allergic reaction to a drug or toxin, an infection, or in association
with cancer or an autoimmune disorder.
Polyarteritis nodosa is caused
by hepatitis B viral infection. Cryoglobulinemia occurs in response to the hepatitis C virus.
Rheumatic diseases, such as
systemic lupus erythematosus, rheumatoid arthritis, Sjögren’s syndrome, and dermatomyositis can cause inflammation
of the blood vessels.
Blood Test Autoimmune
Blood test can
show whether you have abnormal levels of certain blood cells and antibodies in your blood.
People diagnosed with lupus are also
at higher risk of developing fibromyalgia, but studies are ongoing to relate the occurrence of fibromyalgia with
Blood cell cancers such as lymphoma and leukemia can affect the blood vessels by